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BigPeptideList

Kisspeptin-10

Compoundable (Rx)

Reproductive Peptides · Hormone Regulation

Kisspeptin-10 is a neuropeptide that plays a master regulatory role in the reproductive hormone cascade.

What is Kisspeptin-10?

Kisspeptin-10 is a neuropeptide that plays a master regulatory role in the reproductive hormone cascade. It stimulates GnRH (gonadotropin-releasing hormone) release, which in turn triggers LH and FSH production. It is being studied for fertility treatment, hormone optimization, and as an alternative to hCG in testosterone therapy protocols.

Also known as: Kisspeptin, KISS1, KP-10

How Does Kisspeptin-10 Work?

Binds to KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, stimulating GnRH pulse release. This triggers the LH and FSH cascade, making it an upstream regulator of the entire reproductive hormone axis. May also have direct effects on mood and sexual behavior.

What is Kisspeptin-10 Used For?

  • Hormone optimization
  • Fertility support
  • Testosterone support
  • LH/FSH stimulation

Potential Side Effects

  • Injection site irritation
  • Headache (uncommon)
  • Flushing

Contraindications

  • Hormone-sensitive cancers
  • Pregnancy (except under medical supervision)

FDA Legal Status

United States — FDA

Compoundable (Rx)

Category 1 (restored 2026)

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Frequently Asked Questions

What does kisspeptin do for men?
Kisspeptin stimulates the natural production of LH and FSH, which drive testosterone production. It is being explored as an alternative to hCG in TRT protocols for maintaining fertility and natural hormone production. It works upstream of the entire reproductive axis.
Can kisspeptin help with fertility?
Yes. Clinical trials show kisspeptin can trigger egg maturation in IVF protocols with lower risk of ovarian hyperstimulation syndrome (OHSS) compared to hCG. It is being actively studied as a safer alternative for fertility treatment.

Quick Facts

Legal Status (USA)
Compoundable (Rx)
FDA Category
Category 1 (restored 2026)
Evidence Rating
BModerate Evidence (Some Human Data)
Class / Subclass
Reproductive Peptides / Hormone Regulation
Administration
subcutaneous, intravenous
Typical Dosage
100-200mcg daily
Half-Life
~28 minutes
Year Discovered
2001

Sources

PubMed 15539438

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

  1. PubMed PMID 15539438 — peer-reviewed primary literature on Kisspeptin-10.
  2. FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.