The Comprehensive Peptide Database
Research 75+ peptides with evidence ratings, FDA legal status tracking, head-to-head comparisons, dosing protocols, and condition-based guides — every dosing and efficacy claim cited to PubMed, ClinicalTrials.gov, or the FDA.
Trending Peptides
The most researched and discussed peptides right now.
Semaglutide
FDA ApprovedGLP-1 Receptor Agonists
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for type 2 diabetes management and chronic weight management. It mimics the nat...
Tirzepatide
FDA ApprovedGLP-1 Receptor Agonists
Tirzepatide is a first-in-class dual GIP and GLP-1 receptor agonist used for type 2 diabetes and chronic weight management. It produces the most signi...
BPC-157
Compoundable (Rx)Tissue Repair Peptides
BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in human gastric juice. It has shown remarkable ...
Retatrutide
In Clinical TrialsGLP-1 Receptor Agonists
Retatrutide is an investigational triple-action peptide that activates GLP-1, GIP, and glucagon receptors simultaneously. In Phase 2 trials, it produc...
TB-500
Compoundable (Rx)Tissue Repair Peptides
TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in almost all human cells. It plays a crucial ro...
GHK-Cu
Compoundable (Rx)Anti-Aging Peptides
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. It dec...
Browse by Category
Find peptides organized by their primary use case.
Weight Loss Peptides
Peptides used for weight management and fat reduction, including GLP-1 receptor agonists, GIP agonists, and metabolic pe...
6 peptidesTissue Repair & Healing Peptides
Peptides that accelerate the repair of tendons, muscles, ligaments, bones, and other tissues. These peptides promote ang...
3 peptidesGrowth Hormone Peptides
Peptides that stimulate natural growth hormone production through GHRH receptor or ghrelin receptor activation. These in...
6 peptidesAnti-Aging & Longevity Peptides
Peptides researched for their potential to slow or reverse aspects of biological aging, including telomere maintenance, ...
6 peptidesNootropic & Cognitive Peptides
Peptides that enhance cognitive function, including focus, memory, neuroprotection, and neuroplasticity. These range fro...
4 peptidesSexual Function & Libido Peptides
Peptides that improve sexual desire, arousal, and function through melanocortin receptor activation or reproductive horm...
3 peptidesImmune System Peptides
Peptides that modulate or enhance immune function, including antimicrobial peptides and immune regulators. These help ba...
3 peptidesSkincare & Cosmetic Peptides
Topical peptides used in skincare for anti-wrinkle, collagen stimulation, and skin rejuvenation. These are available ove...
3 peptidesGut Health Peptides
Peptides that support gastrointestinal healing, reduce gut inflammation, and improve digestive function. These target co...
2 peptidesFat Loss & Metabolic Peptides
Peptides specifically targeted at fat reduction and metabolic optimization, working through various mechanisms from appe...
3 peptidesSleep & Recovery Peptides
Peptides that improve sleep quality, promote deep sleep, and support overnight recovery. These work through various mech...
3 peptidesPipeline & Upcoming Peptides
Peptide drugs currently in clinical trials or awaiting FDA approval. These represent the next generation of peptide ther...
2 peptidesDiabetes Peptides
Peptides used in the treatment and management of type 2 diabetes, including GLP-1 receptor agonists and dual/triple agon...
3 peptidesMuscle Growth Peptides
Peptides that support muscle development, recovery, and performance through growth hormone stimulation, tissue repair ac...
5 peptidesPopular Comparisons
Head-to-head analysis of commonly compared peptides.
Semaglutide vs Tirzepatide
The two most prescribed weight loss peptides compared. Semaglutide (Ozempic/Wegovy) is a GLP-1 agonist, while tirzepatide (Mounjaro/Zepbound) is a dual GIP/GLP-1 agonist producing greater average weight loss.
BPC-157 vs TB-500
The two most popular tissue repair peptides compared. BPC-157 promotes local healing through angiogenesis, while TB-500 works systemically through actin regulation and cell migration. They are commonly stacked together.
Ipamorelin vs Sermorelin
Two popular growth hormone secretagogues compared. Ipamorelin acts through ghrelin receptors (GHRP), while sermorelin acts through GHRH receptors. They work through different pathways and are often combined.
Semax vs Selank
Two Russian-developed nootropic peptides compared. Semax is primarily a cognitive enhancer (focus, memory, BDNF), while Selank is primarily an anxiolytic (anxiety reduction, calm focus). Both are nasal peptides often used together.
GHK-Cu vs Argireline
Two popular anti-aging skincare peptides compared. GHK-Cu stimulates collagen production and tissue repair from within, while Argireline reduces wrinkles by relaxing facial muscles (topical "Botox alternative").
Semaglutide vs Retatrutide
Current champion vs next-generation challenger. Semaglutide is the FDA-approved GLP-1 agonist, while retatrutide is Eli Lilly's investigational triple agonist (GLP-1/GIP/glucagon) showing even greater weight loss in trials.
Epitalon vs FOXO4-DRI
Two anti-aging peptides with fundamentally different approaches. Epitalon activates telomerase to maintain telomere length, while FOXO4-DRI selectively kills senescent cells. Both target core mechanisms of biological aging.
CJC-1295 vs Ipamorelin
The most commonly combined GH peptide pair, also compared as alternatives. CJC-1295 is a GHRH analog (amplifies GH release), while ipamorelin is a GHRP (triggers GH release). Together they are synergistic.
Peptides by Condition
Find peptides studied for specific health conditions.
Weight Loss & Obesity
Peptides studied for weight management and obesity treatment, from FDA-approved GLP-1 agonists to research compounds tar...
6 peptidesTendon & Ligament Repair
Peptides that accelerate tendon and ligament healing through angiogenesis, cell migration, and tissue remodeling....
3 peptidesMuscle Recovery
Peptides that support muscle repair, reduce recovery time, and promote tissue regeneration after exercise or injury....
4 peptidesGut Health
Peptides that support gastrointestinal healing, reduce gut inflammation, and improve digestive function for conditions l...
2 peptidesCognitive Enhancement
Peptides that improve focus, memory, neuroplasticity, and protect against cognitive decline through BDNF elevation and n...
4 peptidesAnti-Aging & Longevity
Peptides that target core mechanisms of biological aging including telomere maintenance, senescent cell clearance, mitoc...
6 peptidesSexual Health & Libido
Peptides that improve sexual desire, arousal, and function through central nervous system pathways rather than just bloo...
3 peptidesSleep Quality
Peptides that improve sleep architecture, promote deep sleep, and support overnight recovery and hormone production....
3 peptidesInflammation & Pain
Peptides with anti-inflammatory properties that reduce chronic inflammation, modulate immune responses, and support pain...
4 peptidesSkin Health & Rejuvenation
Peptides that improve skin quality through collagen stimulation, wrinkle reduction, wound healing, and overall skin reju...
3 peptidesHair Growth
Peptides that promote hair growth through improved follicle blood flow, growth factor stimulation, and anti-inflammatory...
2 peptidesImmune Support
Peptides that modulate and strengthen immune function, enhance vaccine responses, and support defense against infections...
3 peptidesAnxiety & Stress
Peptides with anxiolytic properties that reduce anxiety and stress without sedation or addiction potential....
2 peptidesWhy BigPeptideList?
Evidence-Based
Every peptide includes evidence ratings backed by published research, PubMed citations, and clinical trial references.
FDA Status Tracking
Up-to-date FDA regulatory status for every peptide, including the 2026 Category 1 bulk-substance restorations.
Comprehensive Database
Over 30 peptides with detailed profiles covering mechanisms, dosing, side effects, FAQs, and head-to-head comparisons.
Neutral & Unbiased
No affiliate links, no product sales. Just factual, research-backed information to help you make informed decisions.
Frequently Asked Questions
What are peptides?
Peptides are short chains of amino acids (typically 2-50) that act as signaling molecules in the body. They bind to specific receptors to trigger biological responses such as tissue repair, hormone release, immune modulation, and metabolic regulation. Unlike proteins, peptides are small enough to be absorbed and utilized efficiently.
Are peptides safe?
Safety varies widely by peptide. FDA-approved peptides like semaglutide and PT-141 have extensive clinical trial data supporting their safety profiles. Research peptides like BPC-157 and TB-500 have strong preclinical safety data but limited human trials. All peptides should be used under medical supervision, sourced from reputable compounding pharmacies, and dosed appropriately.
Are peptides legal in the United States?
Peptide legality in the US depends on the specific peptide and its FDA classification. FDA-approved peptides (semaglutide, tirzepatide, PT-141) require a prescription. As of 2026, many previously restricted peptides (BPC-157, TB-500, GHK-Cu) have been restored to FDA Category 1, making them legally available through compounding pharmacies with a prescription. Some peptides remain research-only.
How are peptides administered?
Most therapeutic peptides are administered via subcutaneous injection using small insulin-type needles. Some peptides are available in oral form (semaglutide as Rybelsus, BPC-157), nasal spray (Semax, Selank), or topical application (GHK-Cu, Argireline). The administration route affects bioavailability and which conditions the peptide is most effective for.
Do I need a prescription for peptides?
FDA-approved peptides always require a prescription. Compoundable peptides (Category 1) require a prescription from a licensed provider and must be dispensed by a licensed compounding pharmacy. Over-the-counter peptides (like Argireline in skincare products) do not require a prescription. Research-only peptides are not intended for human use.
Medical Disclaimer: The information on BigPeptideList is for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. Peptide availability and legal status vary by jurisdiction and may change. Do not use this information to self-diagnose or self-treat any condition.