KPV

Compoundable (Rx)

Anti-Inflammatory Peptides · Gut Health

KPV is a naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH).

What is KPV?

KPV is a naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). It possesses potent anti-inflammatory properties, particularly in the gastrointestinal tract, making it one of the most popular peptides for gut health and inflammatory conditions.

Also known as: Lysine-Proline-Valine, Alpha-MSH fragment

How Does KPV Work?

Enters cells and travels to the nucleus where it inhibits NF-κB inflammatory signaling. Reduces production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). Has direct antimicrobial effects. Crosses the blood-brain barrier and reduces neuroinflammation.

What is KPV Used For?

Gut inflammation
IBD/IBS support
Anti-inflammatory
Skin inflammation

Potential Side Effects

Generally well-tolerated
Mild GI discomfort (oral)
Injection site irritation

Contraindications

Pregnancy
Children
Active infection (may suppress needed inflammation)

FDA Legal Status

United States — FDA

Compoundable (Rx)

Category 1 (restored 2026)

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Frequently Asked Questions

Is KPV good for gut health?

KPV shows strong anti-inflammatory effects in the GI tract by inhibiting NF-κB signaling. Preclinical studies show it reduces colitis and intestinal inflammation. It is increasingly used by practitioners for IBD, IBS, leaky gut, and other inflammatory gut conditions.

Can KPV be taken orally?

Yes. KPV is small enough (just 3 amino acids) to survive digestion and is active orally. Oral administration is particularly effective for gut-related conditions, as it delivers the anti-inflammatory peptide directly to the intestinal lining.

Quick Facts

Legal Status (USA): Compoundable (Rx)
FDA Category: Category 1 (restored 2026)
Evidence Rating: CPreliminary Evidence (Mostly Preclinical)
Class / Subclass: Anti-Inflammatory Peptides / Gut Health
Administration: oral, subcutaneous, topical
Typical Dosage: 200-500mcg 1-2x daily (oral/injectable)
Half-Life: ~2-3 hours
Year Discovered: 2000

Sources

PubMed 16181638

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

PubMed PMID 16181638 — peer-reviewed primary literature on KPV.
FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.