Matrixyl 3000

Over-the-Counter

Cosmetic Peptides · Collagen Stimulation

Matrixyl 3000 is a patented combination of two peptides (palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) designed to stimulate collagen production and reduce skin inflammation.

What is Matrixyl 3000?

Matrixyl 3000 is a patented combination of two peptides (palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) designed to stimulate collagen production and reduce skin inflammation. It is one of the most well-studied cosmetic peptides, shown to reduce wrinkle depth by up to 44% in clinical trials.

Also known as: Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Pal-GHK/Pal-GQPR

How Does Matrixyl 3000 Work?

Palmitoyl tripeptide-1 activates collagen synthesis through TGF-β signaling. Palmitoyl tetrapeptide-7 reduces IL-6 and inflammation that degrades collagen. Together they simultaneously promote new collagen formation while protecting existing collagen from inflammatory breakdown.

What is Matrixyl 3000 Used For?

Collagen stimulation
Anti-wrinkle
Skin firmness
Anti-aging

Potential Side Effects

Skin irritation (rare)

Contraindications

Hypersensitivity to ingredients

FDA Legal Status

United States — FDA

Over-the-Counter

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Frequently Asked Questions

What does Matrixyl 3000 do for skin?

Matrixyl 3000 signals your skin cells to produce more collagen (Types I, III, and IV) while reducing the inflammation that breaks collagen down. Clinical studies show up to 44% wrinkle depth reduction after 2 months of use. It improves skin firmness, texture, and overall appearance.

Quick Facts

Legal Status (USA): Over-the-Counter
Evidence Rating: BModerate Evidence (Some Human Data)
Class / Subclass: Cosmetic Peptides / Collagen Stimulation
Administration: topical
Typical Dosage: 2-8% concentration in serums/creams
Brand Names: Matrixyl 3000
Year Discovered: 2003

Sources

PubMed 19522987

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

PubMed PMID 19522987 — peer-reviewed primary literature on Matrixyl 3000.
FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.