CJC-1295

Compoundable (Rx)

Growth Hormone Secretagogues · GHRH Analog

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates sustained growth hormone release.

What is CJC-1295?

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates sustained growth hormone release. It comes in two forms: with DAC (Drug Affinity Complex) for extended half-life, and without DAC (also called Modified GRF 1-29) for more pulsatile release. Often combined with ipamorelin for synergistic effects.

Also known as: CJC-1295 DAC, CJC-1295 no DAC, Modified GRF 1-29, Mod GRF

How Does CJC-1295 Work?

Mimics natural GHRH by binding to GHRH receptors on the anterior pituitary, stimulating growth hormone synthesis and release. The DAC version binds to albumin in the blood, extending its active duration from minutes to days. Amplifies natural GH pulsatility rather than creating non-physiological sustained elevation.

What is CJC-1295 Used For?

Growth hormone optimization
Anti-aging
Fat loss
Muscle growth
Recovery

Potential Side Effects

Flushing
Headache
Dizziness
Injection site irritation
Water retention

Contraindications

Active cancer
Pregnancy
Pituitary disorders

FDA Legal Status

United States — FDA

Compoundable (Rx)

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Head-to-head comparisons:

CJC-1295 vs Ipamorelin

Frequently Asked Questions

What is the difference between CJC-1295 with DAC and without DAC?

CJC-1295 with DAC has a Drug Affinity Complex that extends its half-life to 6-8 days, providing sustained GH elevation. Without DAC (Mod GRF 1-29), the half-life is ~30 minutes, producing a more natural pulsatile GH release. Most practitioners prefer without DAC combined with ipamorelin.

Why is CJC-1295 often combined with ipamorelin?

CJC-1295 (GHRH analog) and ipamorelin (ghrelin mimetic) work through different receptor pathways to stimulate GH release. Together, they produce a synergistic effect — more GH than either alone — while maintaining a natural pulsatile pattern.

Quick Facts

Legal Status (USA): Compoundable (Rx)
Evidence Rating: BModerate Evidence (Some Human Data)
Class / Subclass: Growth Hormone Secretagogues / GHRH Analog
Administration: subcutaneous
Typical Dosage: 100-200mcg daily (no DAC); 2mg weekly (with DAC)
Half-Life: ~30 minutes (no DAC); 6-8 days (with DAC)
Year Discovered: 2005

Sources

PubMed 16352683

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

PubMed PMID 16352683 — peer-reviewed primary literature on CJC-1295.
FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.