Sermorelin

Compoundable (Rx)

Growth Hormone Secretagogues · GHRH Analog

Sermorelin is a synthetic analog of the first 29 amino acids of natural growth hormone-releasing hormone (GHRH).

What is Sermorelin?

Sermorelin is a synthetic analog of the first 29 amino acids of natural growth hormone-releasing hormone (GHRH). It was one of the first GHRH analogs to be FDA-approved (for pediatric GH deficiency) and remains widely used in anti-aging and hormone optimization clinics as a safer alternative to direct HGH therapy.

Also known as: GHRH(1-29)NH2, Geref

How Does Sermorelin Work?

Binds to GHRH receptors on somatotroph cells in the anterior pituitary, stimulating the synthesis and secretion of growth hormone in a natural pulsatile pattern. Preserves the hypothalamic-pituitary feedback loop, preventing excess GH production.

What is Sermorelin Used For?

Growth hormone deficiency
Anti-aging
Sleep improvement
Fat loss
Muscle maintenance

Potential Side Effects

Injection site reactions
Flushing
Headache
Dizziness
Hyperactivity

Contraindications

Active malignancy
Pregnancy
Hypersensitivity to sermorelin

FDA Legal Status

United States — FDA

Compoundable (Rx)

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Head-to-head comparisons:

Sermorelin vs Ipamorelin

Frequently Asked Questions

Is sermorelin the same as HGH?

No. Sermorelin stimulates your own pituitary gland to produce more GH naturally, while HGH is direct hormone replacement. Sermorelin maintains natural feedback loops and pulsatile release patterns, making it safer for long-term use with fewer side effects.

Why take sermorelin at bedtime?

The largest natural GH pulse occurs during deep sleep. Taking sermorelin at bedtime amplifies this natural pulse, resulting in better GH optimization and improved sleep quality.

Quick Facts

Legal Status (USA): Compoundable (Rx)
Evidence Rating: AStrong Evidence (Multiple RCTs)
Class / Subclass: Growth Hormone Secretagogues / GHRH Analog
Administration: subcutaneous
Typical Dosage: 200-300mcg daily at bedtime
Half-Life: ~10-20 minutes
Brand Names: Geref
Year Discovered: 1980
Approval Year: 1997

Sources

PubMed 2190482

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

PubMed PMID 2190482 — peer-reviewed primary literature on Sermorelin.
FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.