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BigPeptideList

DSIP

Compoundable (Rx)

Nootropic Peptides · Sleep

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide that promotes delta wave (deep) sleep.

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide that promotes delta wave (deep) sleep. It was first isolated from rabbit brain tissue in 1977. Beyond sleep, it has shown effects on stress reduction, pain modulation, and hormone regulation.

Also known as: Delta Sleep-Inducing Peptide, Emideltide

How Does DSIP Work?

Modulates GABAergic neurotransmission, promotes serotonin release, and influences the hypothalamic sleep-wake cycle. Increases delta wave activity during sleep without suppressing REM sleep. Also modulates corticotropin release, reducing stress hormone levels.

What is DSIP Used For?

  • Sleep quality improvement
  • Stress reduction
  • Pain modulation
  • Hormone regulation

Potential Side Effects

  • Drowsiness
  • Vivid dreams
  • Mild headache (uncommon)

Contraindications

  • Pregnancy
  • Severe depression
  • Children

FDA Legal Status

United States — FDA

Compoundable (Rx)

Category 1 (restored 2026)

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Frequently Asked Questions

Does DSIP actually improve sleep?
Research shows DSIP increases delta wave (deep sleep) activity without suppressing REM sleep. Users commonly report deeper, more restorative sleep and easier sleep onset. However, evidence quality is mixed — most studies are older and smaller. Evidence rating: C.
Is DSIP better than melatonin?
DSIP and melatonin work differently. Melatonin primarily helps with sleep onset and circadian rhythm. DSIP specifically promotes delta wave (deep sleep) activity and may improve sleep architecture more broadly. Some practitioners combine both.

Quick Facts

Legal Status (USA)
Compoundable (Rx)
FDA Category
Category 1 (restored 2026)
Evidence Rating
CPreliminary Evidence (Mostly Preclinical)
Class / Subclass
Nootropic Peptides / Sleep
Administration
subcutaneous, nasal, intravenous
Typical Dosage
100-300mcg before bed
Half-Life
~15-25 minutes (but effects last hours)
Year Discovered
1977

Sources

PubMed 6263427

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

  1. PubMed PMID 6263427 — peer-reviewed primary literature on DSIP.
  2. FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.