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Selank

Compoundable (Rx)

Nootropic Peptides · Anxiolytic

Selank is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, developed at the Russian Institute of Molecular Genetics alongside Semax.

What is Selank?

Selank is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, developed at the Russian Institute of Molecular Genetics alongside Semax. It is approved in Russia as an anxiolytic and nootropic. It combines anti-anxiety effects with cognitive enhancement without sedation or addiction potential.

Also known as: TP-7

How Does Selank Work?

Modulates GABA-A receptor expression, enhances serotonin metabolism, and stabilizes brain enkephalins. Increases IL-6 expression and modulates the balance of T-helper cell cytokines. Provides anxiolytic effects through GABAergic enhancement without benzodiazepine-like sedation or dependence.

What is Selank Used For?

  • Anxiety reduction
  • Cognitive enhancement
  • Immune modulation
  • Stress management

Potential Side Effects

  • Nasal irritation
  • Fatigue (rare)
  • Mild allergic reactions (very rare)

Contraindications

  • Pregnancy
  • Autoimmune conditions
  • Children

FDA Legal Status

United States — FDA

Compoundable (Rx)

Category 1 (restored 2026)

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Semax

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DSIP

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Head-to-head comparisons:

Selank vs Semax

Frequently Asked Questions

How does Selank compare to benzodiazepines?
Selank provides anxiolytic effects similar to benzodiazepines but without sedation, cognitive impairment, tolerance, or physical dependence. It actually improves cognition while reducing anxiety, making it a fundamentally different approach to anxiety management.
Can you take Selank and Semax together?
Yes, Selank and Semax are commonly stacked. Semax provides cognitive enhancement and focus, while Selank adds anxiolytic and stress-reducing effects. Together they provide balanced cognitive enhancement with emotional stability.

Quick Facts

Legal Status (USA)
Compoundable (Rx)
FDA Category
Category 1 (restored 2026)
Evidence Rating
BModerate Evidence (Some Human Data)
Class / Subclass
Nootropic Peptides / Anxiolytic
Administration
nasal, subcutaneous
Typical Dosage
250-500mcg nasal, 1-3x daily
Half-Life
~5-10 minutes (rapid onset, sustained effects)
Year Discovered
1996

Sources

PubMed 18577768

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

  1. PubMed PMID 18577768 — peer-reviewed primary literature on Selank.
  2. FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.