GHRP-6

Research Only

Growth Hormone Secretagogues · GHRP

GHRP-6 is one of the original growth hormone releasing peptides.

What is GHRP-6?

GHRP-6 is one of the original growth hormone releasing peptides. It strongly stimulates both GH release and appetite (hunger), making it popular among bodybuilders looking to gain mass. It produces a potent GH pulse but with significant appetite stimulation and cortisol/prolactin effects.

Also known as: Growth Hormone Releasing Peptide-6

How Does GHRP-6 Work?

Potent ghrelin receptor agonist that triggers growth hormone release from the anterior pituitary. Strongly activates the hunger-signaling pathway, producing intense appetite within 15-20 minutes of injection. Also stimulates gastric motility and gastric acid secretion.

What is GHRP-6 Used For?

Growth hormone stimulation
Appetite stimulation
Muscle growth

Potential Side Effects

Intense hunger
Water retention
Cortisol elevation
Prolactin increase
Blood sugar changes

Contraindications

Diabetes
Active cancer
Pregnancy

FDA Legal Status

United States — FDA

Research Only

This peptide is currently investigational and not approved for clinical use.

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Frequently Asked Questions

Why does GHRP-6 make you so hungry?

GHRP-6 is a potent ghrelin receptor agonist, and ghrelin is the body's primary hunger hormone. This strong appetite stimulation is actually desired by some users (bulking) but undesirable for those seeking fat loss. Ipamorelin is preferred if appetite stimulation is unwanted.

Quick Facts

Legal Status (USA): Research Only
Evidence Rating: BModerate Evidence (Some Human Data)
Class / Subclass: Growth Hormone Secretagogues / GHRP
Administration: subcutaneous
Typical Dosage: 100-300mcg 2-3x daily
Half-Life: ~15-60 minutes
Year Discovered: 1998

Sources

PubMed 9849822

Last updated: 2026-04-01

Sources & references

Primary sources used for the dosing, mechanism, side-effect, and regulatory claims on this page. Verify time-sensitive information (regulatory status, prescribing details) on the source before relying on it for medical decisions. See our disclaimer.

PubMed PMID 9849822 — peer-reviewed primary literature on GHRP-6.
FDA Federal Register — official notice record for FDA regulatory actions and Category 1 / 503A bulk-substance updates.